Rapid antimicrobial susceptibility test for identification of new therapeutics and drug combinations against multidrug-resistant bacteria
نویسندگان
چکیده
منابع مشابه
Rapid antimicrobial susceptibility test for identification of new therapeutics and drug combinations against multidrug-resistant bacteria
Current antimicrobial susceptibility testing has limited screening capability for identifying empirical antibiotic combinations to treat severe bacterial infections with multidrug-resistant (MDR) organisms. We developed a new antimicrobial susceptibility assay using automated ultra-high-throughput screen technology in combination with a simple bacterial growth assay. A rapid screening of 5170 a...
متن کاملIn vitro activity of antimicrobial combinations against multidrug-resistant Pseudomonas aeruginosa.
INTRODUCTION Pseudomonas aeruginosa isolates related to nosocomial infections are often resistant to multiple antibacterial agents. In this study, antimicrobial combinations were evaluated to detect in vitro synergy against clinical isolates of P. aeruginosa. METHODS Four clinical P. aeruginosa isolates were selected at random among other isolates from inpatients treated at the public Univers...
متن کاملAntimicrobial Drug Use and Antibiotic-Resistant Bacteria
To the Editor: The article by Harris et al., published in the August 2007 issue of Emerging Infectious Diseases, examined the risk factors for selecting extended-spectrum β-lactamase–producing Enterobacteriaceae in intensive-care patients and found that exposure to piperacillin/tazobactam and vancomycin were independent risk factors (1). Although antimicrobial drug use has been historically lin...
متن کاملIn-vitro effects of various antimicrobial combinations against multidrug- resistant Acinetobacter baumannii strains
In recent years, Acinetobacter strains have emerged as one of the most important nosocomial pathogens, especially in patients admitted to an intensive care unit (ICU). The progressively increasing antibiotic resistance against A. baumannii is now a major problem in our country as it is throughout the world. This resistance against A.baumannii has increased and led clinicians to find alternative...
متن کاملrapid identification of extensively and extremely drug resistant tuberculosis from multidrug resistant strains; using pcr-rflp and pcr-sscp.
background and objectives: resistance in mycobacterium tuberculosis is caused by mutations in genes encoding drug targets. investigators have already demonstrated the existence of mutations in codons 88 to 94 in the gyra gene and also in codons 1400, 1401, and 1483 of rrs gene among extensively and extremely drug resistant tuberculosis (xdr & xxdr-tb) strains. the aim of this study was to ident...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Emerging Microbes & Infections
سال: 2016
ISSN: 2222-1751
DOI: 10.1038/emi.2016.123